概述

  • 产品名称Anti-NCoR2抗体
    参阅全部 NCOR2 一抗
  • 描述
    兔多克隆抗体to NCoR2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    PAPPAPPPPQNL

    , corresponding to amino acids 994-1005 of Human NCoR2

  • 阳性对照
    • Human brain tissue and human lung carcinoma tissue.

应用

Our Abpromise guarantee covers the use of ab74518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/25 for 10 minutes at room temperature.
    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
    • 组织特异性Ubiquitous. High levels of expression are detected in lung, spleen and brain.
    • 序列相似性Belongs to the N-CoR nuclear receptor corepressors family.
      Contains 2 SANT domains.
    • 结构域The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
      The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CTG 26 antibody
      • CTG repeat protein 26 antibody
      • CTG26 antibody
      • N CoR2 antibody
      • N-CoR2 antibody
      • NCoR 2 antibody
      • Ncor2 antibody
      • NCOR2_HUMAN antibody
      • Nuclear Receptor Co-Repressor 2 antibody
      • Nuclear receptor corepressor 2 antibody
      • retinoic-acid-receptor-associated corepressor antibody
      • Silencing Mediator for Retanoid and Thyroid Hormone Receptors antibody
      • Silencing mediator of retinoic acid and thyroid hormone receptor antibody
      • SMAP 270 antibody
      • SMAP270 antibody
      • SMRT antibody
      • SMRTE antibody
      • SMRTE tau antibody
      • T3 receptor associating factor antibody
      • T3 receptor-associating factor antibody
      • Thyroid retinoic acid receptor associated corepressor antibody
      • Thyroid- antibody
      • TNRC 14 antibody
      • TNRC14 antibody
      • TRAC 1 antibody
      • TRAC antibody
      • TRAC1 antibody
      see all

    Anti-NCoR2 antibody 图像

    • ab74518, at 1/25 dilution, staining NCoR2 in formalin fixed, paraffin embedded human brain tissue by Immunohistochemistry.

    Anti-NCoR2 antibody (ab74518)参考文献

    ab74518 has not yet been referenced specifically in any publications.

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