Anti-Nck抗体[NC-20 (same as 20B-1H9)] (ab44950)

概述

  • 产品名称Anti-Nck抗体[NC-20 (same as 20B-1H9)]
    参阅全部 Nck 一抗
  • 描述
    小鼠单克隆抗体[NC-20 (same as 20B-1H9)] to Nck
  • 经测试应用适用于: IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein (Human)

  • 阳性对照
    • A431 cells.

性能

应用

Our Abpromise guarantee covers the use of ab44950 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP
  • 应用说明IP: 1/400 protein lysate (native and denatured). Use Protein G.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2.
    • 序列相似性Contains 1 SH2 domain.
      Contains 3 SH3 domains.
    • 翻译后修饰Phosphorylated on Ser and Tyr residues.
    • 细胞定位Cytoplasm. Endoplasmic reticulum. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Cytoplasmic protein NCK1 antibody
      • Melanoma Nck protein antibody
      • MGC12668 antibody
      • NCK 1 antibody
      • NCK adaptor protein 1 antibody
      • NCK alpha antibody
      • NCK antibody
      • NCK tyrosine kinase antibody
      • Nck-1 antibody
      • NCK1 antibody
      • NCK1_HUMAN antibody
      • NCKalpha antibody
      • Non catalytic region of tyrosine kinase antibody
      • SH2/SH3 adaptor protein NCK alpha antibody
      • SH2/SH3 adaptor protein NCK-alpha antibody
      see all

    Anti-Nck antibody [NC-20 (same as 20B-1H9)] (ab44950)参考文献

    ab44950 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"