概述

  • 产品名称
    NCH 51
  • 描述
    Novel HDAC inhibitor
  • 别名
    • PTACH
  • 生物学描述
    Novel HDAC inhibitor (IC50 values are 32, 48 and 41 nM at HDAC4, HDAC1 and HDAC6, respectively). Induces apoptosis and inhibits cell growth of various malignant cells and tumor cells lines (EC50 = 3.8 μM). Also reactivates latent HIV-1 gene expression.
  • 纯度
    > 99%

性能

文献

This product has been referenced in:
  • Victoriano AF  et al. Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression. FEBS Lett 585:1103-11 (2011). Read more (PubMed: 21402072) »
  • Sanda T  et al. Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. Leukemia 21:2344-53 (2007). Read more (PubMed: 17690692) »
  • Suzuki T  et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem 48:1019-32 (2005). Read more (PubMed: 15715470) »

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