概述

  • 产品名称NBQX
  • 描述
    AMPA / kainate antagonist
  • 生物学描述Potent, selective and competitive AMPA/kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo. Water-soluble form available - please see NBQX disodium salt (ab120046).
  • 纯度> 99%

性能

    NBQX 图像

    • ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with NBQX (ab120045), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of NBQX, as described in literature.
      The cells were incubated at 37°C for 1h in media containing different concentrations of ab120045 (NBQX) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

    NBQX (ab120045)参考文献

    This product has been referenced in:
    • Kew JN & Kemp JA Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) 179:4-29 (2005). Read more (PubMed: 15731895) »
    • Randle JC  et al. Competitive inhibition by NBQX of kainate/AMPA receptor currents and excitatory synaptic potentials: importance of 6-nitro substitution. Eur J Pharmacol 215:237-44 (1992). Read more (PubMed: 1382998) »
    • Sheardown MJ  et al. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia. Science 247:571-4 (1990). Read more (PubMed: 2154034) »

    See all 90 Publications for this product

    Product Wall

    Thank you for confirming these details and for your cooperation.

    As agreed, I have issued a free of charge replacement with the order number ****.

    To check the status of the order please contact our Customer Service team and refer...

    Read More

    Thank you for contacting us.

    Sorry again for the wrong information provided for the reconstitution of NBQX ab120045. Iwould be pleased to send you a free of charge unit of NBQX ab120045 in compensation.In order to do so, could you please sen...

    Read More

    Thank you for contacting us.

    I have checked with the lab, and we can confirm that this compound NBQX ab120045 is not soluble in water and is actually only soluble in DMSO to 100 mM.Thiswas a mistake in our database which has now been updated....

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"