Anti-Nav1.8/SCN10A抗体(ab66743)
Key features and details
- Rabbit polyclonal to Nav1.8/SCN10A
- Suitable for: ICC
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Nav1.8/SCN10A抗体
参阅全部 Nav1.8/SCN10A 一抗 -
描述
兔多克隆抗体to Nav1.8/SCN10A -
宿主
Rabbit -
经测试应用
适用于: ICCmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Nav1.8/SCN10A (C terminal).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab66743于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ICC |
1/100 - 1/1000.
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说明 |
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ICC
1/100 - 1/1000. |
靶标
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功能
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. -
组织特异性
Expressed in the dorsal root ganglia and sciatic nerve. -
疾病相关
Episodic pain syndrome, familial, 2 -
序列相似性
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
Contains 1 IQ domain. -
结构域
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. -
翻译后修饰
Ubiquitinated by NEDD4L; which promotes its endocytosis.
Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. -
细胞定位
Cell membrane. It can be translocated to the cell membrane through association with S100A10. - Information by UniProt
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数据库链接
- Entrez Gene: 6336 Human
- Omim: 604427 Human
- SwissProt: Q9Y5Y9 Human
- Unigene: 250443 Human
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别名
- hPN3 antibody
- mPN3 antibody
- Peripheral nerve sodium channel 3 antibody
see all
图片
实验方案
数据表及文件
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Datasheet download
文献 (4)
ab66743 被引用在 4 文献中.
- Hulme AJ et al. Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons. Front Cell Neurosci 14:600895 (2020). PubMed: 33362470
- Christidis N et al. Expression of 5-HT3 receptors and TTX resistant sodium channels (Na(V)1.8) on muscle nerve fibers in pain-free humans and patients with chronic myofascial temporomandibular disorders. J Headache Pain 15:63 (2014). PubMed: 25261281
- Cejudo-Roman A et al. The voltage-gated sodium channel nav1.8 is expressed in human sperm. PLoS One 8:e76084 (2013). Flow Cyt, ICC/IF ; Human . PubMed: 24086692
- Pinto FM et al. Molecular and functional characterization of voltage-gated sodium channels in human sperm. Reprod Biol Endocrinol 7:71 (2009). ICC/IF ; Human . PubMed: 19607678