概述

  • 产品名称Anti-Nav1.8抗体
    参阅全部 Nav1.8 一抗
  • 描述
    兔多克隆抗体to Nav1.8
  • 经测试应用适用于: ICC, WB, IHC-Frmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Synthetic peptide, corresponding to amino acids 1892-1956 of Nav1.8

性能

应用

Our Abpromise guarantee covers the use of ab63331 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC 1/4000.
WB 1/4000. Predicted molecular weight: 217 kDa.
IHC-Fr Use at an assay dependent concentration.

靶标

  • 功能Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
  • 组织特异性Expressed in the dorsal root ganglia and sciatic nerve.
  • 疾病相关Episodic pain syndrome, familial, 2
  • 序列相似性Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
    Contains 1 IQ domain.
  • 结构域The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
  • 翻译后修饰Ubiquitinated by NEDD4L; which promotes its endocytosis.
    Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
  • 细胞定位Cell membrane. It can be translocated to the cell membrane through association with S100A10.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hPN3 antibody
    • mPN3 antibody
    • Peripheral nerve sodium channel 3 antibody
    • Pn3 (gene name) antibody
    • PN3 antibody
    • SCN10A antibody
    • SCNAA_HUMAN antibody
    • Sensory neuron sodium channel antibody
    • Sns (gene name) antibody
    • SNS antibody
    • Sodium channel protein type 10 subunit alpha antibody
    • Sodium channel protein type X alpha subunit antibody
    • Sodium channel protein type X subunit alpha antibody
    • Voltage-gated sodium channel alpha subunit Nav1.8 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.8 antibody
    see all

Anti-Nav1.8 antibody 图像



  • Predicted band size : 217 kDa
    Western blot analysis. A single band of strong NaV1.8-like immunoreactivity at approximately 240 kDa in the membrane fraction of rat DRG is shown. Note that membrane fractions of rat whole brain, cerebellum, skeletal muscle, heart, superior cervical ganglia, liver and kidney showed no detectable immunoreactivity. Membrane extract from CHO-SNS22 (a cell line stably transfected with rat NaV1.8 cDNA) showed strong immunoreactivity at the same size with DRG. Non-transfected CHO cells did not show any bands.
  • Immunohistochemistry was performed on 2 week old rat lumber DRG sections. NaV1.8-like immunoreactivity can be detected only in small diameter (<30 um) neurons.

Anti-Nav1.8 antibody (ab63331)参考文献

This product has been referenced in:
  • Isensee J  et al. Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci 127:216-29 (2014). Read more (PubMed: 24190886) »

See 1 Publication for this product

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Yes we have antibodies to detect the p47PHOX. The common alternative namesfor p47phox is NCF1, NOXO2 and SH3PXD1A.http://www.uniprot.org/uniprot/P14598

The antibodies we have are; ab74095, ab63331, ab11...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"