This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

概述

  • 产品名称
  • 描述
    山羊多克隆抗体to Nav1.8

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • 特异性
    In preliminary western blot experiments ab114110 gave an ~150kDa band in Rat spinal cord and Mouse NIH3T3 lysates at 1ug/ml. This band was blocked by addition of the immunizing peptide. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 221kDa according to NP_033160.2.
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Dog
  • 免疫原

    Synthetic peptide:

    C-DDNRSLQSDPYNQR

    , corresponding to internal sequence amino acids 471-484 of Mouse Nav1.8 (NP_033160.2).

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, 99.48% Tris buffered saline
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab114110 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 1 kDa.

靶标

  • 功能
    Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
  • 组织特异性
    Expressed in the dorsal root ganglia and sciatic nerve.
  • 疾病相关
    Episodic pain syndrome, familial, 2
  • 序列相似性
    Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
    Contains 1 IQ domain.
  • 结构域
    The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
  • 翻译后修饰
    Ubiquitinated by NEDD4L; which promotes its endocytosis.
    Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
  • 细胞定位
    Cell membrane. It can be translocated to the cell membrane through association with S100A10.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hPN3 antibody
    • mPN3 antibody
    • Peripheral nerve sodium channel 3 antibody
    • Pn3 (gene name) antibody
    • PN3 antibody
    • SCN10A antibody
    • SCNAA_HUMAN antibody
    • Sensory neuron sodium channel antibody
    • Sns (gene name) antibody
    • SNS antibody
    • Sodium channel protein type 10 subunit alpha antibody
    • Sodium channel protein type X alpha subunit antibody
    • Sodium channel protein type X subunit alpha antibody
    • Voltage-gated sodium channel alpha subunit Nav1.8 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.8 antibody
    see all

实验方案

Anti-Nav1.8 antibody (ab114110)参考文献

ab114110 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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