Native大鼠Antithrombin III/ATIII蛋白(ab93317)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Active: Yes
- Suitable for: SDS-PAGE
描述
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产品名称
Native大鼠Antithrombin III/ATIII蛋白
参阅全部 Antithrombin III/ATIII 蛋白酶 -
生物活性
ab93317 is 98% active by Thrombin titration. -
纯度
> 95 % SDS-PAGE.
ab93317 is purified using several chromatographic steps and is > 98% pure by SDS-PAGE. -
表达系统
Native -
蛋白长度
Full length protein -
无动物成分
No -
性质
Native -
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种属
Rat
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技术指标
Our Abpromise guarantee covers the use of ab93317 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
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形式
Liquid -
补充说明
Solubility: > 5 mg/mL
Spectrophotometric Data:
Ultraviolet: Absorbance (280nm) = 0.52 epsilon0.1% = 0.65 Concentration = 0.8 mg/mL
Previously labelled as Antithrombin III.
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.40
Constituents: 0.82% Sodium phosphate, 0.0292% EDTA, 0.58% Sodium chlorideThis product is an active protein and may elicit a biological response in vivo, handle with caution.
常规信息
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别名
- ANT3_HUMAN
- Antithrombin
- Antithrombin III
see all -
功能
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. -
组织特异性
Found in plasma. -
疾病相关
Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. -
序列相似性
Belongs to the serpin family. -
翻译后修饰
Phosphorylation sites are present in the extracelllular medium. -
细胞定位
Secreted > extracellular space. - Information by UniProt
图片
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab93317 尚未被引用在任何文献中。