Anti-Natural Killer Cell抗体[ANK44] (ab36388)

概述

  • 产品名称Anti-Natural Killer Cell抗体[ANK44]
  • 描述
    小鼠单克隆抗体[ANK44] to Natural Killer Cell
  • 特异性ab36388 also binds to rat gamma-delta-TCR T cells. It does not bind to alpha-beta-TCR T cells or to B cells. The antigen recognized by ab36388 is highly expressed on rat NK cells after IL-2-activation. The antigen is not expressed by unstimulated NK cells.
  • 经测试应用适用于: IHC-Fr, IP, Flow Cytmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Preparation of IL-2-activated cultured NK cells (Wag rats)

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: Tissue culture supernatant
  • 纯度Tissue culture supernatant
  • 克隆单克隆
  • 克隆编号ANK44
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab36388 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 相关性Natural killer cells (NK) are a type of lymphocyte and a component of innate immune defense. They share a common progenitor with T cells and have been described as large, granular, bone-marrow derived lymphocytes. These cells do not destroy the attacking microorganisms directly; they attack infected cells and cells that appear that they might be cancer. NK cells are not phagocytic; they weaken the target cell's plasma membrane, causing water and ions to diffuse into the cell and expanding it. Under this large pressure, the target cell lyses. NK cells are characterised immunohistochemically by the presence of CD56 and the absence of CD3 on the cell membrane. NK cells are activated in response to interferons or macrophage-derived cytokines. They serve to contain virus infections while the adaptive immune response is generating antigen specific cytotoxic T cells that can clear the infection. Patients deficient in NK cells prove to be highly susceptible to early phases of herpes virus infection.
  • 别名
    • Large granular lymphocytes antibody
    • LGLs antibody
    • NK cells antibody

Anti-Natural Killer Cell antibody [ANK44] (ab36388)参考文献

This product has been referenced in:
  • Giezeman-Smits KM  et al. Novel monoclonal antibodies against membrane structures that are preferentially expressed on IL-2-activated rat NK cells. J Leukoc Biol 63:209-15 (1998). Read more (PubMed: 9468279) »

See 1 Publication for this product

Product Wall

Following up my previous message, I found the original article describing the production and characterization of the natural killer cell antibody ab36388, clone ANK44. The paper suggests that the protein this antibody recognizes, or at least the epitop...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"