Natural人Uromucoid protein (ab96035)

概述

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • AccessionP07911
    • 种属Human
    • 分子量64 kDa
    • 氨基酸25 to 614

技术指标

Our Abpromise guarantee covers the use of ab96035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Immunodiffusion

    SDS-PAGE

  • 纯度>= 96 % n/a.
    ab96035 is 96% pure
  • 形式Lyophilised
  • 补充说明Starting material tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C.

    Preservative: None
    Constituents: dH2O

  • 复溶Use of de-ionised water is recommended

常规信息

  • 别名
    • ADMCKD2
    • FJHN
    • HNFJ
    • HNFJ1
    • MCKD2
    • medullary cystic kidney disease 2 (autosomal dominant)
    • Tamm Horsfall glycoprotein
    • Tamm Horsfall urinary glycoprotein
    • Tamm-Horsfall urinary glycoprotein
    • THGP
    • THP
    • Umod
    • Urehd1
    • urehr4
    • UROM_HUMAN
    • Uromodulin
    • uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
    • Uromodulin, secreted form
    see all
  • 功能Not known. May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and TNF with high affinity.
  • 组织特异性Synthesized by kidney. Most abundant protein in normal human urine.
  • 疾病相关Defects in UMOD are the cause of familial juvenile hyperuricemic nephropathy type 1 (HNFJ1) [MIM:162000]. HNFJ1 is a renal disease characterized by juvenil onset of hyperuricemia, polyuria, progressive renal failure, and gout. The disease is associated with interstitial pathological changes resulting in fibrosis.
    Defects in UMOD are the cause of medullary cystic kidney disease type 2 (MCKD2) [MIM:603860]. MCKD2 is a form of tubulointerstitial nephropathy characterized by formation of renal cysts at the corticomedullary junction. It is characterized by adult onset of impaired renal function and salt wasting resulting in end-stage renal failure by the sixth decade.
    Defects in UMOD are the cause of glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI) [MIM:609886]. GCKDHI is a renal disorder characterized by a cystic dilation of Bowman space, a collapse of glomerular tuft, and hyperuricemia due to low fractional excretion of uric acid and severe impairment of urine concentrating ability.
  • 序列相似性Contains 3 EGF-like domains.
    Contains 1 ZP domain.
  • 细胞定位Cell membrane. Secreted. Secreted after cleavage in the urine.
  • Information by UniProt

Natural Human Uromucoid protein (ab96035)参考文献

ab96035 has not yet been referenced specifically in any publications.

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