Natural人Plasmin protein (ab92799)

概述

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • AccessionP00747
    • 种属Human
    • 额外的序列信息Source: Human plasma

技术指标

Our Abpromise guarantee covers the use of ab92799 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Activity: 0% on D-VLK chromogenic plasmin substrate.
  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab92799 is prepared from Lys plasmin by active site-specific inactivation with a molar excess of Phe-Pro-Arg chloromethyl ketone, followed by extensive dialysis to remove free inhibitor. Activity: 0% on D-VLK chromogenic plasmin substrate.
  • 形式Liquid
  • 补充说明Solubility: > 2 mg/mL and < 5 mg/mL
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1M Sodium chloride, 0.1M HEPES, pH 7.4

常规信息

  • 别名
    • Plasminogen
    • PLG
  • 相关性Plasmin is an enzyme formed in the circulating blood, and many other extracellular fluids, from the zymogen plasminogen. Plasminogen is a single-chain glycoprotein with 790 amino acid residues. Activation to the active form, plasmin, by urokinase involves cleavage at the arg-val bond between residues 560 and 561, resulting in the formation of the 2-chain plasmin molecule held together by 2 disulfide linkages. The heavier chain contains about 411 residues and the lighter chain about 233. The main function of plasmin is the digestion of fibrin in blood clots. Plasmin is a proteolytic enzyme with a specificity similar to that of trypsin. Like trypsin, plasmin belongs to the family of serine proteinases, in which the active site catalytic triad, his-57, asp-102, and ser-195 (chymotrypsin numbering), is situated in the light chain. Plasmin acts as a proteolytic factor in a variety of processes other than fibrinolysis; including embryonic development, tissue remodelling, tumour invasion and inflammation; in ovulation it weakens the walls of the Graafian follicle. A Deficiency of plasmin may lead to thrombosis, as clots are not degraded adequately.
  • 细胞定位Secreted

Natural Human Plasmin protein (ab92799)参考文献

ab92799 has not yet been referenced specifically in any publications.

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