Native人IgG FC fragment蛋白(ab90285)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
描述
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产品名称
Native人IgG FC fragment蛋白
参阅全部 Human IgG FC fragment 蛋白酶 -
生物活性
Shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 and 2 by FDA approved tests. -
纯度
> 95 % SDS-PAGE. -
表达系统
Native -
蛋白长度
Full length protein -
无动物成分
No -
性质
Native -
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预测分子量
50 kDa -
额外的序列信息
Prepared from plasma
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab90285 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
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形式
Liquid -
补充说明
Protein Determination: Extinction Coefficient (E) 0.1% at 280nm =1.46.
IgG is cleaved using Papain to product the Fc fragment. The IgG fc fragment does not bind antigen; however, it does contain the classic antigenic determinants and biological activity with respect to cytotrophic reactions, binding of complement and catabolic rate control.
Shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 and 2 by FDA approved tests.
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Preservative: 0.05% Sodium azide
Constituents: 0.79% Tris HCl, 1.16% Sodium chloride
常规信息
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相关性
The Fc region is the constant region on an immunoglobulin molecule, the area that is exactly the same on all antibodies. The Fc region is found on the heavy chains and is not involved in binding antigens.
图片
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (12)
ab90285 被引用在 12 文献中.
- Ma L et al. FOSL1 knockdown ameliorates DSS-induced inflammation and barrier damage in ulcerative colitis via MMP13 downregulation. Exp Ther Med 24:551 (2022). PubMed: 35978937
- Kamalakar A et al. JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling. Bone 143:115657 (2021). PubMed: 32980561
- Qiu Y et al. Upregulation of AQP2 mediated by transcription factor FOXO1 inhibits TGF-ß-induced fibrosis in human urothelial cells. Exp Ther Med 22:1388 (2021). ChIP ; Human . PubMed: 34650636
- Vilhelmsson Timmermand O et al. A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen. Cancers (Basel) 13:N/A (2021). PubMed: 34298682
- Bill M et al. EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid Leukemia. Clin Cancer Res 26:669-678 (2020). PubMed: 31672772