Natural人Heparin Cofactor II protein (ab62249)

概述

描述

  • 性质
    Native
  • 来源
    Native
  • 氨基酸序列
    • 种属
      Human

技术指标

Our Abpromise guarantee covers the use of ab62249 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Functional Studies

  • 形式
    Liquid
  • 补充说明
    Concentartion varies from lot to lot but is between 5-10mg/ml
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol

常规信息

  • 别名
    • D22S673
    • HC II
    • HC-II
    • HC2
    • HCF2
    • HEP2_HUMAN
    • Heparin cofactor 2
    • Heparin cofactor II
    • HLS2
    • Leuserpin 2
    • LS2
    • Protease inhibitor leuserpin 2
    • Protease inhibitor leuserpin-2
    • serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
    • Serpin D1
    • serpin peptidase inhibitor, clade D (heparin cofactor), member 1
    • SERPIND1
    • THPH10
    see all
  • 功能
    Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
    Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
  • 组织特异性
    Expressed predominantly in liver. Also present in plasma.
  • 疾病相关
    Thrombophilia due to heparin cofactor 2 deficiency
  • 序列相似性
    Belongs to the serpin family.
  • 结构域
    The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
  • 翻译后修饰
    Phosphorylation sites are present in the extracellular medium.
  • Information by UniProt

文献

ab62249 has not yet been referenced specifically in any publications.

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