• 产品名称
  • 蛋白长度
    Full length protein


  • 性质
  • 来源
  • 氨基酸序列
    • 种属


Our Abpromise guarantee covers the use of ab77858 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot


  • 纯度
    > 95 % SDS-PAGE.
    >96% pure (SDS-PAGE), Multi-step procedure including ion exchange chromatography. 0.96mg hemoglobin/mg powder (Coomassie) (prior to lyophilization).
  • 形式
  • 补充说明
    All human source materials have tested negative for HIV1, HIV2, HCV antibodies, HBsAg and HIV Antigen by approved FDA methods. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
  • Concentration information loading...


  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: Sodium chloride


  • 别名
    • 3-prime alpha-globin gene
    • Alpha 2 globin chain
    • Alpha globin
    • alpha one globin
    • alpha-1 globin
    • Alpha-globin
    • Beta globin
    • CD113t C
    • CD31
    • Delta globin
    • Erythremia, beta-globin type, included
    • Gamma 1 globin
    • Hb F Agamma
    • HBA
    • HBA 1
    • HBA 2
    • HBA T3
    • HBA-T2
    • HBA1
    • HBA2
    • HBB
    • Hbb-y
    • HBD
    • Hbe1
    • HBG
    • HBG 1
    • HBG1
    • HBGA
    • HBGR
    • HBH
    • Hemoglobin alpha 1
    • hemoglobin alpha 1 globin chain
    • Hemoglobin alpha chain
    • Hemoglobin alpha locus
    • Hemoglobin alpha locus 1
    • hemoglobin alpha-1 chain
    • Hemoglobin beta
    • Hemoglobin beta chain
    • Hemoglobin beta chain complex
    • Hemoglobin beta locus
    • Hemoglobin gamma
    • Hemoglobin gamma 1 chain
    • Hemoglobin gamma A
    • Hemoglobin gamma A chain
    • Hemoglobin subunit alpha
    • Hemoglobin subunit beta
    • Hemoglobin subunit gamma 1
    • hemoglobin, gamma, regulator of
    • Hemoglobin--gamma locus, 136 alanaine
    • HSGGL1
    • LVV-hemorphin-7
    • Methemoglobinemia, beta-globin type, included
    • MGC126895
    • MGC126897
    • Minor alpha-globin locus
    • PRO2979
    see all
  • 功能
    Involved in oxygen transport from the lung to the various peripheral tissues.
  • 组织特异性
    Red blood cells.
  • 疾病相关
    Defects in HBA1/HBA2 may be a cause of Heinz body anemias (HEIBAN) [MIM:140700]. This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency.
    Defects in HBA1/HBA2 are the cause of alpha-thalassemia (A-THAL) [MIM:604131]. The thalassemias are the most common monogenic diseases and occur mostly in Mediterranean and Southeast Asian populations. The hallmark of alpha-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. The level of alpha chain production can range from none to very nearly normal levels. Deletion of both copies of each of the two alpha-globin genes causes alpha(0)-thalassemia, also known as homozygous alpha thalassemia. Due to the complete absence of alpha chains, the predominant fetal hemoglobin is a tetramer of gamma-chains (Bart hemoglobin) that has essentially no oxygen carrying capacity. This causes oxygen starvation in the fetal tissues leading to prenatal lethality or early neonatal death. The loss of three alpha genes results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia known as hemoglobin H disease. Untreated, most patients die in childhood or early adolescence. The loss of two alpha genes results in mild alpha-thalassemia, also known as heterozygous alpha-thalassemia. Affected individuals have small red cells and a mild anemia (microcytosis). If three of the four alpha-globin genes are functional, individuals are completely asymptomatic. Some rare forms of alpha-thalassemia are due to point mutations (non-deletional alpha-thalassemia). The thalassemic phenotype is due to unstable globin alpha chains that are rapidly catabolized prior to formation of the alpha-beta heterotetramers.
    Note=Alpha(0)-thalassemia is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.
  • 序列相似性
    Belongs to the globin family.
  • 翻译后修饰
    The initiator Met is not cleaved in variant Thionville and is acetylated.
  • Information by UniProt


ab77858 has not yet been referenced specifically in any publications.


Thank you for your enquiry.

This productab77858 Hemoglobin proteinhas tested negative for HIV1, HIV2, HCV antibodies, HBsAg and HIV Antigen by approved FDA methods. However, please bear in mind that no test guarantees a product to be no...

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Thank you for contacting us. The Human Hemoglobin protein ab77858 is fully saturated with iron. This product is readily oxidized by air so it is likely to contain methemoglobin, but the level of methemoglobin content is not determined. I hope this help...

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Thank you for contacting us.

The positive control ab77858 should work with ab401.

Please be advised we have not used these products together. Our assumption is only based on the ...

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Thank you for contacting us.

The lab let me know that the protein (Human Hemoglobin, ab77858), can be reconstituted using deionized water.The product can be reconstituted to whatever concentration is suitable for your experiment.


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Thank you for your inquiry. Please see my comments to the two products of interest below. ab77943, Alpha-1-acid glycoprotein (human):  This protein can be reconstituted in deionized water.  The protein can then be stored at -80C for several years...

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