Natural人Hemoglobin A1c protein (ab98306)

概述

  • 产品名称Natural人Hemoglobin A1c protein
  • 蛋白长度Full length protein

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • AccessionP69905
    • 种属Human
    • 分子量15 kDa
    • 氨基酸2 to 142

技术指标

Our Abpromise guarantee covers the use of ab98306 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度 96 % .
    ab98306 was sterile filtered through a 0.2µm membrane. Purity >96% as determined by FPLC using a Mono S Haemoglobin A1c column (dispensing solution).
  • 形式Liquid
  • 补充说明Starting material donor tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -20ºC. Avoid freeze / thaw cycles.

    Proprietary buffer formulation, pH 8.0.

常规信息

  • 别名
    • Beta-globin
    • HBB
    • HBB_HUMAN
    • Hemoglobin beta chain
    • Spinorphin
    see all
  • 功能Involved in oxygen transport from the lung to the various peripheral tissues.
    LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.
    Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
  • 组织特异性Red blood cells.
  • 疾病相关Heinz body anemias
    Beta-thalassemia
    Sickle cell anemia
    Beta-thalassemia, dominant, inclusion body type
  • 序列相似性Belongs to the globin family.
  • 翻译后修饰Glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage. This takes place slowly and continuously throughout the 120-day life span of the red blood cell. The rate of glycation is increased in patients with diabetes mellitus.
    S-nitrosylated; a nitric oxide group is first bound to Fe(2+) and then transferred to Cys-94 to allow capture of O(2).
    Acetylated on Lys-60, Lys-83 and Lys-145 upon aspirin exposure. PubMed:16916647 reports the identification of HBB acetylated on Lys-145 in the cytosolic fraction of HeLa cells. This may have resulted from contamination of the sample.
  • Information by UniProt

Natural Human Hemoglobin A1c protein (ab98306)参考文献

ab98306 has not yet been referenced specifically in any publications.

Product Wall

The haemoglobin A1c ab98306 is a native protein and prepared from packed red blood cells; the protein should be intact, so it is glycated full length.

 The tetramer molecular weight is 64KDa consisting of 4 subunits of 16KDa

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"