Natural人Haptoglobin protein (ab90924)

概述

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab90924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Lyophilised
  • 补充说明Protein Determination: Extinction Coefficient (E) 0.1% at 280nm, 1cm pathway = 1.20. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20ºC.

    De-ionized H2O

常规信息

  • 别名
    • Binding peptide
    • BP
    • Haptoglobin alpha chain
    • Haptoglobin alpha(1S) beta
    • Haptoglobin alpha(2FS) beta
    • Haptoglobin beta chain
    • Haptoglobin, alpha polypeptide
    • Haptoglobin, beta polypeptide
    • HP
    • HP2 ALPHA2
    • HP2ALPHA2
    • HPA1S
    • HPT
    • HPT_HUMAN
    • MGC111141
    • Zonulin
    see all
  • 功能As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
    Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
  • 组织特异性Expressed by the liver and secreted in plasma.
  • 疾病相关Anhaptoglobinemia
  • 序列相似性Belongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.
    Contains 2 Sushi (CCP/SCR) domains.
  • 细胞定位Secreted.
  • Information by UniProt

Natural Human Haptoglobin protein 图像

  • SDS-PAGE analysis of ab90924: 4-12% Bis-Tris-HCl NuPAGE gel
    Lane 1: Haptoglobin - 5 µg (reduced/ heated)
    Lane 2: Haptoglobin - 10 µg (reduced/ heated)
    Lane 3: Haptoglobin - 20 µg (reduced/ heated)
    Lane 4: Molecular weight markers
    Lane 5: Haptoglobin - 5 µg (non-reduced/ no heat)
    Lane 6: Haptoglobin - 10 µg (non-reduced/ no heat)
    Lane 7: Haptoglobin - 20 µg (non-reduced/ no heat)

Natural Human Haptoglobin protein (ab90924)参考文献

ab90924 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your reply.

I just checked our current stock of these proteins and they should both arrive lyophilized. For ab90924, the concentration indicated on the printed datasheet (4.76 mg/mL) will reflect the volume from which the protei...

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Thank you for contacting us.

These proteins are provided in lyophilized form and as such, the concentrations will be reconstitution dependent. I hope this helps, please let me know if you need any additional information or assistance.

Thank you for your recent telephone enquiry.
I can confirm the following information regarding our haptoglobin proteins:

ab77872 Haptoglobin protein
This protein is purified from a mix of donors and so contains all 3 forms.
<...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"