Native人Factor XIIIa蛋白(Active) (ab62412)
Key features and details
- Expression system: Native
- Purity: > 95% Ion Exchange Chromatography
- Active: Yes
- Suitable for: SDS-PAGE
描述
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产品名称
Native人Factor XIIIa蛋白(Active) -
生物活性
This product has an activity range of 39 U/mg to 200 U/mg
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纯度
> 95 % Ion Exchange Chromatography.
Plasma FXIIIa was generated by cleavage of homogenous plasma FXIII by alpha-thrombin, in the presence of EDTA. This product was then purified by ion and affinity chromatography. -
表达系统
Native -
蛋白长度
Full length protein -
无动物成分
No -
性质
Native -
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种属
Human
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab62412 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
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形式
Liquid -
补充说明
Enzymatic FXIIIa is composed of A2'B2. Ab62412 is the active, enzymatic tetrameric form (A2'B2) in absence of calcium ions. In contrast to the inactive tetrameric FXIII (A2B2), ab62412 has been activated by thrombin.
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 0.0146% EDTA, 50% Glycerol
This product is an active protein and may elicit a biological response in vivo, handle with caution.
常规信息
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别名
- bA525O21.1 (coagulation factor XIII, A1 polypeptide)
- Coagulation factor XIII A chain
- Coagulation factor XIII A1 polypeptide
see all -
功能
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. -
疾病相关
Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. -
序列相似性
Belongs to the transglutaminase superfamily. Transglutaminase family. -
翻译后修饰
The activation peptide is released by thrombin. -
细胞定位
Cytoplasm. Secreted. Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma. - Information by UniProt
图片
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab62412 尚未被引用在任何文献中。