Natural人Factor XIa protein (ab62411)

概述

  • 产品名称Natural人Factor XIa protein
  • 蛋白长度Full length protein

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab62411 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Functional Studies

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 50% H2O

常规信息

  • 别名
    • coagulation factor XI
    • Coagulation factor XIa light chain
    • F11
    • FA11_HUMAN
    • FXI
    • MGC141891
    • Plasma thromboplastin antecedent
    • Platelet coagulation factor XI
    • PTA
    see all
  • 功能Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
  • 组织特异性Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
  • 疾病相关Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
  • 序列相似性Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
    Contains 4 apple domains.
    Contains 1 peptidase S1 domain.
  • 翻译后修饰Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
  • 细胞定位Secreted.
  • Information by UniProt

Natural Human Factor XIa protein (ab62411)参考文献

ab62411 has not yet been referenced specifically in any publications.

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