Native人FXI蛋白(ab62538)
Key features and details
- Expression system: Native
- Purity: > 95% Affinity purified
- Suitable for: SDS-PAGE
描述
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产品名称
Native人FXI蛋白 -
纯度
> 95 % Affinity purified.
FXI is purified from fresh frozen plasma that is stabilized by added inhibitors. The plasma is first treated with BaCl2 to remove the vitamin K-dependent proteins, and FXI is then isolated by affinity chromatography. A final chromatography step on heparin sepharose yields a homogeneous preparation of intact FXI. -
表达系统
Native -
蛋白长度
Full length protein -
无动物成分
No -
性质
Native -
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种属
Human
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技术指标
Our Abpromise guarantee covers the use of ab62538 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
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形式
Liquid -
补充说明
Previously labelled as Factor XI.
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 50% Glycerol, 50% Water
50% H2O
常规信息
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别名
- Coagulation factor XI
- Coagulation factor XIa light chain
- F11
see all -
功能
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. -
组织特异性
Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. -
疾病相关
Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. -
序列相似性
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain. -
翻译后修饰
Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. -
细胞定位
Secreted. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab62538 尚未被引用在任何文献中。