Natural人Factor VII protein (ab62386)

概述

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab62386 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Functional Studies

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol

常规信息

  • 别名
    • Coagulation factor VII
    • coagulation factor VII (serum prothrombin conversion accelerator)
    • Eptacog alfa
    • F7
    • FA7_HUMAN
    • Factor VII
    • Factor VII heavy chain
    • Factor VII light chain
    • FVII coagulation protein
    • OTTHUMP00000018733
    • OTTHUMP00000018734
    • Proconvertin
    • Serum prothrombin conversion accelerator
    • SPCA
    see all
  • 功能Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
  • 组织特异性Plasma.
  • 疾病相关Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:227500]. FA7D is a rare hereditary hemorrhagic disease. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Numerous subjects are completely asymptomatic despite a very low F7 level.
  • 序列相似性Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • 翻译后修饰The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 细胞定位Secreted.
  • Information by UniProt

Natural Human Factor VII protein (ab62386)参考文献

ab62386 has not yet been referenced specifically in any publications.

Product Wall

The concentration of our factor VII is obtained by UV, using an extinction coefficient: E 1% 1cm , 280 nm = 13.9.

Thanks for your reply and for your patience. I apologize for the extended delay in getting more information about this protein. My contact at the lab has said that the SDS-PAGE profile of reduced Factor VII and VIIa are distinct. Reduced and non...

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Thank you for your call yesterday and for your patience while I have been in touch with the lab. Based on SDS-PAGE, the Factor VII protein ab62386 does not contain detectable levels of Factor VIIa. I hope this information will be useful...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"