Natural人Collagen V protein (ab7537)

概述

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • AccessionP20908
    • 种属Human
    • 分子量184 kDa
    • 额外的序列信息Prepared from Human Placenta and is chromatographically and immunologically pure.

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技术指标

Our Abpromise guarantee covers the use of ab7537 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Collagen taken from human species.
  • 应用

    Western blot

    Immunoprecipitation

    ELISA

  • 形式Liquid
  • 补充说明

    This product is free from other collagens, human serum proteins and non-collagen extracellular matrix proteins. This product reacts with anti-Collagen Type V. Reaction with anti-Collagen I, II, III, IV or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).

    Collagen taken from human species.

    Denaturing and reducing conditions will greatly diminish reactivity and selectivity of this protein.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.01% Sodium azide
    Constituent: 0.06% Acetic acid

常规信息

  • 别名
    • AB collagen
    • Alpha 1 type V collagen
    • Alpha 2 type V collagen
    • CO5A1_HUMAN
    • COL5A1
    • Col5A2
    • COL5A2 protein
    • Col5A3
    • Collagen alpha 1(V) chain
    • Collagen alpha 2 (V) chain precursor
    • Collagen alpha 2(V) chain
    • Collagen alpha 3(V) chain
    • Collagen alpha-1(V) chain
    • Collagen fetal membrane A polypeptide
    • Collagen type V alpha 1
    • Collagen type V alpha 2
    • Collagen type V alpha 3
    • Collagen V alpha 2 polypeptide
    • CollagenV
    • MGC105115
    • OTTHUMP00000064637
    • Pro alpha 1 type V collagen
    • Pro alpha 3(V) collagen
    • Procollagen alpha 2(V)
    • Type V preprocollagen alpha 2 chain
    see all
  • 功能Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
  • 疾病相关Ehlers-Danlos syndrome 1
    Ehlers-Danlos syndrome 2
  • 序列相似性Belongs to the fibrillar collagen family.
    Contains 1 fibrillar collagen NC1 domain.
    Contains 1 laminin G-like domain.
  • 结构域The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
  • 翻译后修饰Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    Sulfated on 40% of tyrosines.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Natural Human Collagen V protein (ab7537)参考文献

ab7537 has not yet been referenced specifically in any publications.

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