Natural人Carboxypeptidase B2 protein (ab81749)

概述

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • 种属Human
    • 氨基酸23 to 423

技术指标

Our Abpromise guarantee covers the use of ab81749 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Specific Activity: 2.0-9.2 units/mg. Specific activity is determined by a kinetic assay using Hippuryl-L-Arginine as substrate. One unit equals one micromole of Hippuryl-L-Arginine hyrolyzed per minute. Specific activity is reported in Units per milligram.
  • 应用

    Functional Studies

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20mM HEPES, 150mM Sodium chloride, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • 1110032P04Rik
    • 4930405E17Rik
    • bA139H14.2
    • Carboxypeptidase B like protein
    • Carboxypeptidase U
    • CarboxypeptidaseB2
    • CarboxypeptidaseU
    • CP B2
    • CPB 2
    • CPB2
    • CPU
    • PCPB
    • Plasma carboxypeptidase B
    • Plasma carboxypeptidase B2
    • Procarboxypeptidase B
    • Procarboxypeptidase R
    • Procarboxypeptidase U
    • TAFI
    • Thrombin activable fibrinolysis inhibitor
    • Thrombin activatable fibrinolysis inhibitor
    see all
  • 相关性This protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine and arginine residues. It circulates in plasma as a zymogen with molecular weight of 55 kDa (401 amino acid residues; pI 5.0). Being activated by thrombin-thrombomodulin complex during blood coagulation, it exerts carboxypeptidase activity. Activated carboxypeptidase B2 removes C-terminal lysine residues from fibrin, which is necessary for plasminogen binding to fibrin. This prevents plasminogen from activation into plasmin and retards the lysis of a fibrin clot. The concentration in plasma of healthy people is 5 – 10 µg/ml. High plasma levels were found in patients with stable angina pectoris and angiographically verified coronary artery disease. Elevated concentration in blood is considered as a risk factor for venous thrombosis. A deficiency might contribute to the severity of bleeding disorders in hemophilias A and B, and decreased levels are found in chronic liver disease.
  • 细胞定位Secreted

Natural human Carboxypeptidase B2 protein (ab81749)参考文献

ab81749 has not yet been referenced specifically in any publications.

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