The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
补充说明Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.
Butyrylcholinesterase enzyme assay: One unit of Butyrylcholinesterase will hydrolyse 1.0µ mole of Butyrylcholine per min at pH 8.0 at 37°C.
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Shipped at 4°C. Store at +4°C.
Constituents: 0.02M Ammonium bicarbonate. May contain traces of buffer salts.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
复溶Use of a phosphate buffer pH >7.0 containing 0.15M NaCl is recommended.
Choline esterase II
Cholinesterase (serum) 2
功能Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
组织特异性Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
疾病相关Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
序列相似性Belongs to the type-B carboxylesterase/lipase family.