Natural人Butyrylcholinesterase protein (ab96367)

概述

描述

  • 性质
    Native
  • 来源
    Native
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      65 kDa
    • 氨基酸
      29 to 602

技术指标

Our Abpromise guarantee covers the use of ab96367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性

    >100 U/mg.

  • 应用

    Functional Studies

    SDS-PAGE

  • 形式
    Lyophilised
  • 补充说明
    Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies. Butyrylcholinesterase enzyme assay: One unit of Butyrylcholinesterase will hydrolyse 1.0µ mole of Butyrylcholine per min at pH 8.0 at 37°C.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C.

    Preservative: None
    Constituents: 0.02M Ammonium bicarbonate. May contain traces of buffer salts.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶
    Use of a phosphate buffer pH >7.0 containing 0.15M NaCl is recommended.

常规信息

  • 别名
    • Acylcholine acylhydrolase
    • BCHE
    • Butyrylcholine esterase
    • CHE1
    • CHE2
    • CHLE_HUMAN
    • Choline esterase II
    • Cholinesterase
    • Cholinesterase (serum) 2
    • Cholinesterase 1
    • E1
    • Pseudocholinesterase
    • Pseudocholinesterase E1
    see all
  • 功能
    Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
  • 组织特异性
    Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
  • 疾病相关
    Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
  • 序列相似性
    Belongs to the type-B carboxylesterase/lipase family.
  • 细胞定位
    Secreted.
  • Information by UniProt

文献

ab96367 has not yet been referenced specifically in any publications.

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