Natural人Alpha 1 microglobulin protein (ab96148)

概述

描述

  • 性质
    Native
  • 来源
    Native
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      30 kDa
    • 氨基酸
      20 to 203

技术指标

Our Abpromise guarantee covers the use of ab96148 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Radial Immunodiffusion

    SDS-PAGE

  • 形式
    Lyophilised
  • 补充说明
    Starting material tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C.

    Preservative: None
    Constituents: 0.02M Ammonium bicarbonate
    (May contain traces of buffer salts)

  • 复溶
    Reconstitution in phosphate buffer, pH >7.0 containing 0.15M NaCl is recommended.

常规信息

  • 别名
    • A1M
    • Alpha 1 microglobulin/bikunin precursor
    • Alpha 1 microglycoprotein
    • Alpha-1 microglycoprotein
    • Alpha-1-microglobulin
    • AMBP
    • AMBP_HUMAN
    • Bikunin
    • Complex-forming glycoprotein heterogeneous in charge
    • EDC1
    • Growth inhibiting protein 19
    • HCP
    • HI-30
    • HI30
    • IATIL
    • ITI
    • ITI-LC
    • ITIL
    • Microglobulin (alpha 1)
    • Protein AMBP
    • Protein HC
    • Trypstatin
    • Uristatin
    • Uronic-acid-rich protein
    • UTI
    see all
  • 功能
    Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.
    Trypstatin is a trypsin inhibitor.
  • 组织特异性
    Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin inhibitor is present in plasma and urine.
  • 序列相似性
    In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
    Contains 2 BPTI/Kunitz inhibitor domains.
  • 翻译后修饰
    The precursor is proteolytically processed into separately functioning proteins.
    3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.
    Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate.
    Addition of glycosaminoglycan chondroitin sulfate, allows cross-linking between the different components.
  • 细胞定位
    Secreted.
  • Information by UniProt

文献

ab96148 has not yet been referenced specifically in any publications.

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