Natural人Alpha 1 microglobulin protein (ab38131)

概述

描述

  • 性质Natural
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab38131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Expressed by the liver and secreted in plasma.
  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 纯度> 95 % SDS-PAGE.
    Purified from the urine of patients with chronic renal tubular proteinuria.
  • 形式Liquid
  • 补充说明Expressed by the liver and secreted in plasma.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5

常规信息

  • 别名
    • A1M
    • Alpha 1 microglobulin/bikunin precursor
    • Alpha 1 microglycoprotein
    • Alpha-1 microglycoprotein
    • Alpha-1-microglobulin
    • AMBP
    • AMBP_HUMAN
    • Bikunin
    • Complex-forming glycoprotein heterogeneous in charge
    • EDC1
    • Growth inhibiting protein 19
    • HCP
    • HI-30
    • HI30
    • IATIL
    • ITI
    • ITI-LC
    • ITIL
    • Microglobulin (alpha 1)
    • Protein AMBP
    • Protein HC
    • Trypstatin
    • Uristatin
    • Uronic-acid-rich protein
    • UTI
    see all
  • 功能Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.
    Trypstatin is a trypsin inhibitor.
  • 组织特异性Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin inhibitor is present in plasma and urine.
  • 序列相似性In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
    Contains 2 BPTI/Kunitz inhibitor domains.
  • 翻译后修饰The precursor is proteolytically processed into separately functioning proteins.
    3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.
    Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate.
    Addition of glycosaminoglycan chondroitin sulfate, allows cross-linking between the different components.
  • 细胞定位Secreted.
  • Information by UniProt

Natural Human Alpha 1 microglobulin protein (ab38131)参考文献

ab38131 has not yet been referenced specifically in any publications.

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