Natural人alpha 1 Antichymotrypsin protein (ab80517)

概述

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab80517 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20mM Tris, 150mM Sodium chloride, pH 7.4

  • 复溶Reconstitute with deionized water.

常规信息

  • 别名
    • SERPINA3
    • AACT
    • AACT_HUMAN
    • ACT
    • Alpha-1-antichymotrypsin His-Pro-less
    • Antichymotrypsin
    • Cell growth inhibiting gene 24/25 protein
    • Cell growth-inhibiting gene 24/25 protein
    • GIG24
    • GIG25
    • Growth inhibiting protein 24
    • Growth inhibiting protein 25
    • MGC88254
    • Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase, antitrypsin) member 3
    • Serine (or cysteine) proteinase inhibitor clade A member 3
    • Serine proteinase inhibitor clade A member 3
    • Serpin A3
    • Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3
    • SERPINA3
    see all
  • 功能Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
  • 组织特异性Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
  • 疾病相关Defects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].
  • 序列相似性Belongs to the serpin family.
  • 结构域The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
  • 细胞定位Secreted.
  • Information by UniProt

Natural Human alpha 1 Antichymotrypsin protein 图像

Natural Human alpha 1 Antichymotrypsin protein (ab80517)参考文献

ab80517 has not yet been referenced specifically in any publications.

Product Wall

Abreviews
Application Functional Studies
Cathepsin G activity was measured spectrofluorometrically (Spectra Max Gemini EM) at 320 nm for excitation and 420 nm for emission using Abz-TPFSGQ-EDDnp at 15 µM final (Genecust) as the substrate in PBS at 37 °C. Cathepsin G at 1 µM was previously incubated for 10 min at 37°C with or without Human alpha 1 Antichymotrypsin protein (ab80517) at 1 µM or 0.5 µM in PBS.

"Valayer Alexandre
Centre d'Etude des Pathologies Respiratoires (CEPR)
INSERM U1100
Faculté de Médecine, Université F. Rabelais
10, boulevard Tonnellé
37032 Tours cedex "
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Ms. SECRETARIAT CEPR U1100

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提交于 Jun 22 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"