Natural Cyclosporin A protein (ab73731)

概述

  • 产品名称Natural Cyclosporin A protein
  • 蛋白长度Full length protein

描述

  • 性质Natural
  • 氨基酸序列
    • 序列Chemically, cyclosporin is designated as [R-[R*,R*-(E)]]-cyclic(L-alanyl-D-alanyl-N-methyl- L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydr oxy-N, 4-dimethyl-L-2-amino-6-octenoyl-L-alpha-amino-buty ryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-met hyl-L-leucyl). Molecular Formula: C62H111N11O12.
    • 分子量1 kDa
    • 额外的序列信息Cyclosporin is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids and having a molecular weight of 1202.64.

技术指标

Our Abpromise guarantee covers the use of ab73731 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None

  • 复溶Reconstitute the lyophilized Cyclosporin A in sterile 18Megaohm-cm H2O at not less than 100µg/ml, which can then be further diluted to other aqueous solutions

常规信息

  • 相关性Cyclosporin is used to prevent rejection following solid organ and bone marrow transplantation . It has been estimated that cyclosporine is given to more than 90% of children who have received a kidney transplant in the United States. In addition, the ability of cyclosporin to inhibit T-cell activation has been shown to have a role in the treatment of diseases such as nephrotic syndrome, refractory Crohn's disease and ulcerative colitis, biliary cirrhosis, aplastic anemia, rheumatoid arthritis, myasthenia gravis, and dermatomyositis.
  • 细胞定位Cytoplasmic

Natural Cyclosporin A protein (ab73731)参考文献

ab73731 has not yet been referenced specifically in any publications.

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