Natural牛Thrombin protein (ab62389)

概述

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • 种属Cow
    • 额外的序列信息Prepared from purified prothrombin using a modification of the Lundblad procedure as described by Nesheim et al. 1983.

技术指标

Our Abpromise guarantee covers the use of ab62389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Functional Studies

  • 形式Liquid
  • 补充说明Concentration varies from lot to lot but is between 5-10mg/ml
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol

常规信息

  • 别名
    • Coagulation factor II
    • Coagulation factor II thrombin
    • EC 3.4.21.5
    • F2
    • Factor II
    • Prepro coagulation factor II
    • Prothrombin
    • Prothrombin B chain
    • PT
    • RPRGL2
    • Serine protease
    • THPH1
    • THRB_HUMAN
    • Thrombin heavy chain
    see all
  • 功能Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
  • 组织特异��Expressed by the liver and secreted in plasma.
  • 疾病相关Factor II deficiency
    Ischemic stroke
    Thrombophilia due to thrombin defect
    Pregnancy loss, recurrent, 2
  • 序列相似性Belongs to the peptidase S1 family.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 2 kringle domains.
    Contains 1 peptidase S1 domain.
  • 翻译后修饰The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.
    N-glycosylated. N-glycan heterogeneity at Asn-121: Hex3HexNAc3 (minor), Hex4HexNAc3 (minor) and Hex5HexNAc4 (major). At Asn-143: Hex4HexNAc3 (minor) and Hex5HexNAc4 (major).
  • 细胞定位Secreted, extracellular space.
  • Information by UniProt

Natural Cow Thrombin protein (ab62389)参考文献

ab62389 has not yet been referenced specifically in any publications.

Product Wall

Vielen Dank für Ihre Anfrage. Leider sind beide unserer Thrombin Proteine, purifizierte Proteine ohne Tag.  Wir haben daher nicht ein His-Tag-Thrombin aktuell in unserem Katalog. Ich werde jedoch mit meinen Kollegen schauen, ob wir in Planung haben ein...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"