Secreted protein acidic cysteine rich (osteonectin)
功能Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
序列相似性Belongs to the SPARC family. Contains 1 EF-hand domain. Contains 1 follistatin-like domain. Contains 1 Kazal-like domain.
发展阶段Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.
细胞定位Secreted > extracellular space > extracellular matrix > basement membrane. In or around the basement membrane.