The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. Purity was determined to be >95% by densitometry.
ab89813 (Histone H1 protein) can be utilized as a substrate for the following active protein Kinases:
ab104618 (Active human CDK1 + CCNB1 full length protein) ab64299 (Active human CDK1 + Cyclin A2 full length protein) ab51407 (Active human CDK2 + Cyclin A2 full length protein) ab85639 (Active human CDK2 + CCNE1 full length protein) ab177582 (Active human CCNO full length protein) ab85643 (Active human CDK3 + CCNE1 full length protein) ab60761 (Human p35 + p25 full length protein)
ab177586 (Active human PCTAIRE1 protein fragment) ab177576 (Active human PFTK1 (CDK14)/CyclinY full length protein)
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
功能May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.
序列相似性Belongs to the histone H1/H5 family. Contains 1 H15 (linker histone H1/H5 globular) domain.