Natural牛Factor V protein (ab62236)

概述

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • 种属Cow
    • 额外的序列信息Source = fresh bovine plasma

技术指标

Our Abpromise guarantee covers the use of ab62236 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Functional Studies

  • 形式Liquid
  • 补充说明Concentartion varies from lot to lot but is between 5-10mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol

常规信息

  • 别名
    • Activated protein C cofactor
    • APC cofactor
    • Coagulation factor V
    • coagulation factor V (proaccelerin, labile factor)
    • coagulation factor V jinjiang A2 domain
    • Coagulation factor V light chain
    • F5
    • FA5_HUMAN
    • Factor V Leiden
    • FactorV
    • FVL
    • Labile factor
    • PCCF
    • Proaccelerin
    • proaccelerin, labile factor
    • Protein C cofactor
    • RPRGL1
    • THPH2
    see all
  • 功能Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
  • 组织特异性Plasma.
  • 疾病相关Factor V deficiency
    Thrombophilia due to activated protein C resistance
    Budd-Chiari syndrome
    Ischemic stroke
    Pregnancy loss, recurrent, 1
  • 序列相似性Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 2 F5/8 type C domains.
    Contains 6 plastocyanin-like domains.
  • 结构域Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
  • 翻译后修饰Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
    Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
    Activated protein C inactivates factor V and factor Va by proteolytic degradation.
    Phosphorylation sites are present in the extracellular medium.
  • 细胞定位Secreted.
  • Information by UniProt

Natural Cow Factor V protein (ab62236)参考文献

ab62236 has not yet been referenced specifically in any publications.

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