Natural牛CRYGD protein (ab113186)



  • 性质Native
  • 来源Native
  • 氨基酸序列
    • AccessionP08209
    • 种属Cow
    • 分子量19 kDa
    • 氨基酸1 to 174
    • 额外的序列信息Source = bovine eye lens


Our Abpromise guarantee covers the use of ab113186 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot


  • 纯度>= 90 % SDS-PAGE.
    ab113186 is purified by multi-step chromatography.
  • 形式Liquid
  • Concentration information loading...


  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS


  • 别名
    • CACA
    • CCA3
    • CCP
    • CRYG4
    • Crygd
    • Crystallin, gamma D
    • Crystallin, gamma-4
    • CTRCT4
    • Gamma crystallin D
    • Gamma D crystallin
    • Gamma-crystallin 4
    • Gamma-crystallin D
    • Gamma-D-crystallin
    • PCC
    see all
  • 功能Crystallins are the dominant structural components of the vertebrate eye lens.
  • 疾病相关Defects in CRYGD are a cause of cataract autosomal dominant (ADC) [MIM:604219]. Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract is the most common treatable cause of visual disability in childhood.
    Defects in CRYGD are the cause of cataract congenital non-nuclear polymorphic autosomal dominant (CCP) [MIM:601286]; also known as polymorphic congenital cataract. A congenital cataract characterized by a non-progressive phenotype and partial opacity that has a variable location between the fetal nucleus of the lens and the equator. The fetal nucleus is normal. The opacities are irregular and look similar to a bunch of grapes and may be present simultaneously in different lens layers.
    Defects in CRYGD are the cause of cataract congenital cerulean type 3 (CCA3) [MIM:608983]; also known as congenital cataract blue dot type 3. A cerulean form of autosomal dominant congenital cataract. Cerulean cataract is characterized by peripheral bluish and white opacifications organized in concentric layers with occasional central lesions arranged radially. The opacities are observed in the superficial layers of the fetal nucleus as well as the adult nucleus of the lens. Involvement is usually bilateral. Visual acuity is only mildly reduced in childhood. In adulthood, the opacifications may progress, making lens extraction necessary. Histologically the lesions are described as fusiform cavities between lens fibers which contain a deeply staining granular material. Although the lesions may take on various colors, a dull blue is the most common appearance and is responsible for the designation cerulean cataract.
    Defects in CRYGD are the cause of cataract crystalline aculeiform (CACA) [MIM:115700]. A congenital crystalline cataract characterized by fiberglass-like or needle-like crystals projecting in different directions, through or close to the axial region of the lens. The opacity causes a variable degree of vision loss.
  • 序列相似性Belongs to the beta/gamma-crystallin family.
    Contains 4 beta/gamma crystallin 'Greek key' domains.
  • 结构域Has a two-domain beta-structure, folded into four very similar Greek key motifs.
  • Information by UniProt

Natural Cow CRYGD protein 图像

  • SDS-PAGE showing ab112186
    Lane 1: 1.0µg protein
    Lane 2: 2.0µg protein
    Lane 3: 5.0µg protein

Natural Cow CRYGD protein (ab113186)参考文献

ab113186 has not yet been referenced specifically in any publications.

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