Natural牛Collagen VI protein (ab7531)

概述

描述

  • 性质Natural
  • 来源Native
  • 氨基酸序列
    • 种属Cow

技术指标

Our Abpromise guarantee covers the use of ab7531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    Immunoprecipitation

    ELISA

  • 形式Liquid
  • 补充说明

    This product reacts with anti-Collagen Type VI. Reaction with anti-Collagen I, II, III, IV or V is negligible (typically less than 1% cross reactivity was detected by ELISA).

    This product is not recommended for use under denaturing conditions in WB, IP, and ELISA. We would suggest testing it under native conditions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 0.1M Sodium Acetate. pH 4.5

常规信息

  • 别名
    • Alpha 1 (VI) chain (61 AA)
    • CO6A1_HUMAN
    • COL6A1
    • COL6A2
    • COL6A3
    • Collagen alpha 2(VI) chain
    • Collagen alpha 3(VI) chain
    • Collagen alpha-1(VI) chain
    • Collagen type VI alpha 1
    • Collagen type VI alpha 2
    • Collagen type VI alpha 3
    • Collagen VI alpha 1 polypeptide
    • Collagen VI alpha 2 polypeptide
    • Collagen VI alpha 3 polypeptide
    • CollagenVI
    • Human mRNA for collagen VI alpha 2 C terminal globular domain
    • OPLL
    • PP3610
    see all
  • 功能Collagen VI acts as a cell-binding protein.
  • 疾病相关Defects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.
    Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD) [MIM:254090]; also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
  • 序列相似性Belongs to the type VI collagen family.
    Contains 3 VWFA domains.
  • 翻译后修饰Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Natural Cow Collagen VI protein (ab7531)参考文献

ab7531 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam regarding our Collagen VI proteins.


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Thank you for your recent technical enquiry. Because these proteins exist as chains in polymeric form, a precise MW is difficult to obtain. However, the average MW for these products ranges between 80kD and 120kD. I hope this information is helpful...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"