Anti-Natriuretic肽Receptor B抗体(ab14157)

概述

性能

应用

Our Abpromise guarantee covers the use of ab14157 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100. Predicted molecular weight: 117 kDa.
IHC-Fr 1/10000.

靶标

  • 功能Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
  • 疾病相关Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth.
  • 序列相似性Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
    Contains 1 guanylate cyclase domain.
    Contains 1 protein kinase domain.
  • 翻译后修饰Phosphorylation of the protein kinase-like domain is required for full activation by CNP.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AMDM antibody
    • ANP-B antibody
    • ANPB antibody
    • ANPR-B antibody
    • ANPRB antibody
    • ANPRB_HUMAN antibody
    • Atrial natriuretic peptide B type receptor antibody
    • Atrial natriuretic peptide receptor 2 antibody
    • Atrial natriuretic peptide receptor type B antibody
    • Atrionatriuretic peptide receptor B antibody
    • GC-B antibody
    • GCB antibody
    • Guanylate cyclase B antibody
    • GUC 2B antibody
    • GUC2B antibody
    • GUCY2B antibody
    • Natriuretic peptide receptor B antibody
    • Natriuretic peptide receptor B/guanylate cyclase B antibody
    • NPR-B antibody
    • Npr2 antibody
    • NPRB antibody
    • NPRBi antibody
    see all

Anti-Natriuretic Peptide Receptor B antibody (ab14157)参考文献

ab14157 has not yet been referenced specifically in any publications.

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