Anti-Natriuretic肽Receptor A抗体(ab40817)


  • 产品名称Anti-Natriuretic肽Receptor A抗体
    参阅全部 Natriuretic Peptide Receptor A 一抗
  • 描述
    兔多克隆抗体to Natriuretic肽Receptor A
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 750 - 850 of Human Natriuretic Peptide Receptor A.

    (Peptide available as ab41439.)

  • 阳性对照
    • This antibody gave a positive signal in Kidney (Human) Tissue Lysate - adult normal tissue



Our Abpromise guarantee covers the use of ab40817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 140 kDa (predicted molecular weight: 119 kDa).
ICC/IF Use a concentration of 1 µg/ml.


  • 功能Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
  • 序列相似性Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
    Contains 1 guanylate cyclase domain.
    Contains 1 protein kinase domain.
  • 翻译后修饰Phosphorylation of the protein kinase-like domain is required for full activation by ANP.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANP-A antibody
    • ANPa antibody
    • ANPR-A antibody
    • ANPRA antibody
    • ANPRA_HUMAN antibody
    • Atrial natriuretic peptide A type receptor antibody
    • Atrial natriuretic peptide receptor 1 antibody
    • Atrial natriuretic peptide receptor A antibody
    • Atrial natriuretic peptide receptor type A antibody
    • Atrionatriuretic peptide receptor A antibody
    • GC A antibody
    • GC-A antibody
    • Guanylate cyclase A antibody
    • Guanylate cyclase antibody
    • GUC2A antibody
    • GUCY2A antibody
    • Natriuretic peptide A type receptor antibody
    • Natriuretic peptide receptor A/guanylate cyclase A antibody
    • NPR-A antibody
    • NPR1 antibody
    • NPRA antibody
    see all

Anti-Natriuretic Peptide Receptor A antibody 图像

  • Anti-Natriuretic Peptide Receptor A antibody (ab40817) at 1 µg/ml + Human kidney tissue lysate - total protein (ab30203) at 10 µg

    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Performed under reducing conditions.

    Predicted band size : 119 kDa
    Observed band size : 140 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 60 kDa. We are unsure as to the identity of these extra bands.
  • ICC/IF image of ab40817 stained human HEK 293 cells. The cells were methanol fixed (5 min), permabilised in TBS-T (20 min) and incubated with the antibody (ab40817, 1µg/ml) for 1h at room temperature. 1%BSA / 10% normal goat serum / 0.3M glycine was used to quench autofluorescence and block non-specific protein-protein interactions. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red). DAPI was used to stain the cell nuclei (blue).

Anti-Natriuretic Peptide Receptor A antibody (ab40817)参考文献

ab40817 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (PFA perfusion fixed frozen sections)
Sample Rat Tissue sections (Brain sections)
Specification Brain sections
Fixative Paraformaldehyde
Antigen retrieval step None
Permeabilization No

Dr. Sophie Pezet

Verified customer

提交于 Jun 05 2009