概述

  • 产品名称Anti-NASP抗体
    参阅全部 NASP 一抗
  • 描述
    兔多克隆抗体to NASP
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide within Human NASP aa 626-675 (internal sequence). The exact sequence is proprietary.
    Sequence:

    KEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLV


    Database link: NP_689511

  • 阳性对照
    • HepG2 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab94779 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 85 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
  • 组织特异性Isoform 1 is testis- and sperm-specific.
  • 序列相似性Belongs to the NASP family.
    Contains 3 TPR repeats.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
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    • FLJ31599 antibody
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    • MGC19722 antibody
    • MGC20372 antibody
    • MGC2297 antibody
    • MGC93869 antibody
    • NASP antibody
    • NASP_HUMAN antibody
    • nuclear autoantigenic sperm protein (histone binding) antibody
    • Nuclear autoantigenic sperm protein antibody
    • PRO1999 antibody
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    see all

Anti-NASP antibody 图像

  • Anti-NASP antibody (ab94779) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 85 kDa
    Gel concentration: 12%

    Note: the observed bank corresponds to isoform 2.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling NASP with ab94779 at 5µg/ml.

Anti-NASP antibody (ab94779)参考文献

ab94779 has not yet been referenced specifically in any publications.

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