概述

  • 产品名称Anti-NALP6抗体
    参阅全部 NALP6 一抗
  • 描述
    兔多克隆抗体to NALP6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 167-197 of Human NALP6 (NP_612202.1).

  • 阳性对照
    • Human placenta tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab116007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 99 kDa.

靶标

  • 功能As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism.
  • 组织特异性Expressed in peripheral blood leukocytes, predominantly in granulocytes and, at lower levels, in CD4(+) and CD8(+) T-cells. Expressed in colonic myofibroblasts (at protein level) (PubMed:21593405).
  • 序列相似性Belongs to the NLRP family.
    Contains 5 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
    Contains 1 pyrin domain.
  • 细胞定位Cytoplasm. Inflammasome. Cell membrane. Nucleus membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Angiotensin II/vasopressin receptor antibody
    • AVR antibody
    • CLR11.4 antibody
    • NACHT, leucine rich repeat and PYD containing 6 antibody
    • NACHT, LRR and PYD containing protein 6 antibody
    • NACHT, LRR and PYD domains-containing protein 6 antibody
    • NAVR antibody
    • NAVR/AVR antibody
    • NLR family, pyrin domain containing 6 antibody
    • Nlrp6 antibody
    • NLRP6_HUMAN antibody
    • Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 6 antibody
    • PAN3 antibody
    • PYPAF5 antibody
    • PYRIN containing APAF1 like protein 5 antibody
    • PYRIN-containing APAF1-like protein 5 antibody
    see all

Anti-NALP6 antibody 图像

  • Anti-NALP6 antibody (ab116007) at 1/100 dilution + Human placenta tissue lysate at 35 µg

    Predicted band size : 99 kDa

Anti-NALP6 antibody (ab116007)参考文献

ab116007 has not yet been referenced specifically in any publications.

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