概述

  • 产品名称Anti-NALP2抗体
    参阅全部 NALP2 一抗
  • 描述
    兔多克隆抗体to NALP2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to 12 amino acids near the carboxy-terminus of human NALP2.

  • 阳性对照
    • PC-3 cell lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab36850 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 96 kDa (predicted molecular weight: 121 kDa).

靶标

  • 功能Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • 组织特异性Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
  • 序列相似性Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • 结构域The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.
    When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CLR19.9 antibody
    • FLJ20510 antibody
    • Leucine rich repeat and PYD containing protein 2 antibody
    • LRR and PYD domains-containing protein 2 antibody
    • NACHT antibody
    • NACHT domain antibody
    • NACHT leucine rich repeat and PYD containing 2 antibody
    • NACHT LRR and PYD domains containing protein 2 antibody
    • NALP2 antibody
    • NALP2_HUMAN antibody
    • NBS1 antibody
    • NLR family pyrin domain containing 2 antibody
    • NLRP2 antibody
    • Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2 antibody
    • Nucleotide-binding site protein 1 antibody
    • PAN1 antibody
    • PYPAF2 antibody
    • PYRIN containing APAF1 like protein2 antibody
    • PYRIN domain and NACHT domain-containing protein 1 antibody
    • PYRIN-containing APAF1-like protein 2 antibody
    see all

Anti-NALP2 antibody 图像

Anti-NALP2 antibody (ab36850)参考文献

This product has been referenced in:
  • Ji S  et al. Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. Infect Immun 77:1044-52 (2009). WB ; Human . Read more (PubMed: 19103770) »

See 1 Publication for this product

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Thank you for your enquiry. I am sorry to hear that you are experiencing difficulties with this product ab36850 in western blot. Often it is possible to make suggestions that help resolve problems. We will happily offer technical support and in the ...

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