概述

  • 产品名称Anti-NALP2抗体
    参阅全部 NALP2 一抗
  • 描述
    山羊多克隆抗体to NALP2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    C-TEKHHPWAERPSSHD

    , corresponding to C terminal amino acids 1045-1059 of Human NALP2 according to NP_060322.1.

  • 阳性对照
    • Transfected HEK293 cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab118394 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 121 kDa.

靶标

  • 功能Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • 组织特异性Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
  • 序列相似性Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • 结构域The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.
    When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CLR19.9 antibody
    • FLJ20510 antibody
    • Leucine rich repeat and PYD containing protein 2 antibody
    • LRR and PYD domains-containing protein 2 antibody
    • NACHT antibody
    • NACHT domain antibody
    • NACHT leucine rich repeat and PYD containing 2 antibody
    • NACHT LRR and PYD domains containing protein 2 antibody
    • NALP2 antibody
    • NALP2_HUMAN antibody
    • NBS1 antibody
    • NLR family pyrin domain containing 2 antibody
    • NLRP2 antibody
    • Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2 antibody
    • Nucleotide-binding site protein 1 antibody
    • PAN1 antibody
    • PYPAF2 antibody
    • PYRIN containing APAF1 like protein2 antibody
    • PYRIN domain and NACHT domain-containing protein 1 antibody
    • PYRIN-containing APAF1-like protein 2 antibody
    see all

Anti-NALP2 antibody 图像

  • Lane 1 : Anti-NALP2 antibody (ab118394) at 1 µg/ml (incubation time: 1 hour)
    Lane 2 : Anti-NALP2 antibody (ab118394) at 1 mg/ml (incubation time: 1 hour)

    Lane 1 : lysate from HEK293 cells transiently transfected with a vector overexpressing NALP2
    Lane 2 : lysate from mock transfected HEK293 cells

    Lysates/proteins at 10 µg per lane.

    Developed using the ECL technique

    Predicted band size : 121 kDa

Anti-NALP2 antibody (ab118394)参考文献

ab118394 has not yet been referenced specifically in any publications.

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