概述

  • 产品名称Anti-NALP12抗体
    参阅全部 NALP12 一抗
  • 描述
    小鼠单克隆抗体to NALP12
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-110 of Human NALP12

性能

应用

Our Abpromise guarantee covers the use of ab57906 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
    • 组织特异性Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
    • 疾病相关Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.
    • 序列相似性Belongs to the NLRP family.
      Contains 1 DAPIN domain.
      Contains 8 LRR (leucine-rich) repeats.
      Contains 1 NACHT domain.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CLR19.3 antibody
      • FCAS2 antibody
      • Monarch 1 antibody
      • Monarch-1 antibody
      • NACHT, leucine rich repeat and PYD containing 12 antibody
      • NACHT, LRR and PYD containing protein 12 antibody
      • NACHT, LRR and PYD domains-containing protein 12 antibody
      • NAL12_HUMAN antibody
      • NLR family, pyrin domain containing 12 antibody
      • NLRP12 antibody
      • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 antibody
      • OTTHUMP00000067227 antibody
      • PAN6 antibody
      • PYPAF7 antibody
      • PYRIN containing APAF1 like protein 7 antibody
      • PYRIN-containing APAF1-like protein 7 antibody
      • Regulated by nitric oxide antibody
      • RNO antibody
      • RNO2 antibody
      see all

    Anti-NALP12 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57906 NALP12 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    Anti-NALP12 antibody (ab57906)参考文献

    This product has been referenced in:
    • Ataide MA  et al. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog 10:e1003885 (2014). Read more (PubMed: 24453977) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab57906.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"