Anti-NADPH oxidase 4抗体(ab116502)

概述

  • 产品名称Anti-NADPH oxidase 4抗体
    参阅全部 NADPH oxidase 4 一抗
  • 描述
    兔多克隆抗体to NADPH oxidase 4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 123-153 of Human NOX4 (NP_001137308.1, NP_058627.1).

  • 阳性对照
    • CEM cell line lysate.

性能

应用

Our Abpromise guarantee covers the use of ab116502 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 67 kDa.

靶标

  • 功能Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity.
  • 组织特异性Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells.
  • 序列相似性Contains 1 FAD-binding FR-type domain.
    Contains 1 ferric oxidoreductase domain.
  • 发展阶段Expressed in fetal kidney and fetal liver.
  • 翻译后修饰Isoform 3 and isoform 4 are N-glycosylated. Isoform 4 glycosylation is required for its proper function.
  • 细胞定位Endoplasmic reticulum membrane. Cell membrane. Cell junction > focal adhesion. Nucleus. May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Kidney oxidase-1 antibody
    • Kidney superoxide-producing NADPH oxidase antibody
    • KOX 1 antibody
    • KOX antibody
    • Kox-1 antibody
    • NADPH antibody
    • NADPH oxidase 4 antibody
    • Nox4 antibody
    • NOX4_HUMAN antibody
    • Renal NAD(P)H-oxidase antibody
    • RENOX antibody
    see all

Anti-NADPH oxidase 4 antibody 图像

  • Anti-NADPH oxidase 4 antibody (ab116502) at 1/100 dilution + CEM cell line lysate at 35 µg

    Predicted band size : 67 kDa

Anti-NADPH oxidase 4 antibody (ab116502)参考文献

ab116502 has not yet been referenced specifically in any publications.

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