The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 2 µg/ml.
Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 23 kDa (predicted molecular weight: 13 kDa).
功能May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
组织特异性Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.
序列相似性Belongs to the BEX family.
结构域The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR.
翻译后修饰Ubiquitinated. Degraded by the proteasome.
细胞定位Nucleus. Cytoplasm. Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria.
ab21303 at 2µg/ml staining NADE in human brain tissue by IHC
Anti-NADE antibody (ab21303)参考文献
This product has been referenced in:
Xiao L & Tsutsui T Three-dimensional epithelial and mesenchymal cell co-cultures form early tooth epithelium invagination-like structures: Expression patterns of relevant molecules. J Cell Biochem : (2012).
Read more (PubMed: 22234822) »