Anti-NADase抗体(ab127942)
Key features and details
- Rabbit polyclonal to NADase
- Suitable for: WB, IP, Neutralising
- Isotype: IgG
概述
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产品名称
Anti-NADase抗体 -
描述
兔多克隆抗体to NADase -
宿主
Rabbit -
特异性
ab127942 reacts with NADase of Group A, C,and G origins -
经测试应用
适用于: WB, IP, Neutralisingmore details -
种属反应性
与反应: Streptococcus sp. group C, Streptococcus sp. group A -
免疫原
Purified recombinant NADase of Group C hemolytic streptococci expressed in E. coli (Q5R2E3).
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阳性对照
- Culture supernatants of hemolytic streptococci.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. -
存储溶液
pH: 6
Preservative: 0.09% Sodium azide
Constituent: 99% Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab127942于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/2000 - 1/10000. Predicted molecular weight: 50 kDa.
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IP |
Use at an assay dependent dilution.
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Neutralising |
Use at an assay dependent dilution.
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说明 |
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WB
1/2000 - 1/10000. Predicted molecular weight: 50 kDa. |
IP
Use at an assay dependent dilution. |
Neutralising
Use at an assay dependent dilution. |
靶标
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相关性
NAD (nicotinamide adenine dinucleotide) hydrolyzing enzyme is one of the extracellular enzymes and toxins produced by hemolytic streptococci. Although its function as a toxin is largely unknown, it has been suggested to be related to pathogenicity of acute infection. NADase is produced not only by Group A hemolytic streptococci but also by Group C and Group G strains. The amino acid sequences are highly conserved among them and the antibodies cross react each other. Upon infection of hemolytic streptococci, the antibody titer to the NADase increases similarly to anti SLO (Strreptolysin O) antibody. -
别名
- nga antibody
图片
数据表及文件
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Datasheet download
文献 (6)
ab127942 被引用在 6 文献中.
- Liu P et al. Dexmedetomidine alleviated neuropathic pain in dorsal root ganglion neurons by inhibition of anaerobic glycolysis activity and enhancement of ROS tolerance. Biosci Rep 40:N/A (2020). PubMed: 32285913
- Zhu L et al. Intergenic Variable-Number Tandem-Repeat Polymorphism Upstream of rocA Alters Toxin Production and Enhances Virulence in Streptococcus pyogenes. Infect Immun 84:2086-93 (2016). PubMed: 27141081
- Zhu L et al. A molecular trigger for intercontinental epidemics of group A Streptococcus. J Clin Invest 125:3545-59 (2015). PubMed: 26258415
- Minami M et al. Clindamycin-induced CovS-mediated regulation of the production of virulent exoproteins streptolysin O, NAD glycohydrolase, and streptokinase in Streptococcus pyogenes. Antimicrob Agents Chemother 54:98-102 (2010). PubMed: 19805566
- Kimoto H et al. Genetic and biochemical properties of streptococcal NAD-glycohydrolase inhibitor. J Biol Chem 281:9181-9 (2006). PubMed: 16380378
- Stevens DL et al. Molecular epidemiology of nga and NAD glycohydrolase/ADP-ribosyltransferase activity among Streptococcus pyogenes causing streptococcal toxic shock syndrome. J Infect Dis 182:1117-28 (2000). PubMed: 10979908