概述

  • 产品名称Anti-Nac1抗体
    参阅全部 Nac1 一抗
  • 描述
    山羊多克隆抗体to Nac1
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Horse, Cow, Dog, Chimpanzee, Rhesus monkey, Opossum
  • 免疫原

    Synthetic peptide:

    KTEQQESDSVQC

    , corresponding to internal sequence amino acids 167-178 of Human Nac1

  • 阳性对照
    • Bone Marrow lysate.

性能

应用

Our Abpromise guarantee covers the use of ab60264 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明Peptide ELISA: antibody detection limit dilution 1/2000.
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 57 kDa (predicted molecular weight: 57 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
    • 组织特异性Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
    • 序列相似性Contains 1 BEN domain.
      Contains 1 BTB (POZ) domain.
    • 细胞定位Nucleus. Cytoplasm. Distribution in the cytoplasm is dependent on phosphorylation.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BEND8 antibody
      • BTB Domain Containing 14B antibody
      • BTB/POZ domain-containing protein 14B antibody
      • btbd14b antibody
      • FLJ37383 antibody
      • NAC-1 antibody
      • NAC1 antibody
      • Nacc1 antibody
      • NACC1_HUMAN antibody
      • Nucleus accumbens-associated protein 1 antibody
      see all

    Anti-Nac1 antibody 图像

    • ab60264 antibody (0.5µg/ml) staining of Nac1 in Human Bone Marrow lysate (35µg protein in RIPA buffer)

      Predicted band size : 57 kDa
      Observed band size : 57 kDa

    Anti-Nac1 antibody (ab60264)参考文献

    ab60264 has not yet been referenced specifically in any publications.

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