The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Detects a band of approximately 122 kDa (predicted molecular weight: 122 kDa).
功能Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.
组织特异性Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.
序列相似性Contains 7 C2HC-type zinc fingers.
结构域Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence.
Predicted band size : 122 kDa Observed band size : 122 kDa Additional bands at : 140 kDa (possible post-translational modification).
Anti-Myt1 antibody (ab30997)参考文献
This product has been referenced in:
Yokoyama A et al. Identification of Myelin Transcription Factor 1 (MyT1) as a Subunit of the Neural Cell Type-specific Lysine-specific Demethylase 1 (LSD1) Complex. J Biol Chem289:18152-18162 (2014).
Read more (PubMed: 24828497) »
Kishimoto N et al. Interhemispheric asymmetry of olfactory input-dependent neuronal specification in the adult brain. Nat Neurosci16:884-8 (2013).
Read more (PubMed: 23685722) »