Anti-Myosin, smooth muscle heavy chain 1 and 2抗体[SPM201], prediluted (ab17811)

概述

  • 产品名称Anti-Myosin, smooth muscle heavy chain 1 and 2抗体[SPM201], prediluted
    参阅全部 Myosin, smooth muscle heavy chain 1 and 2 一抗
  • 描述
    小鼠单克隆抗体[SPM201] to Myosin, smooth muscle heavy chain 1 and 2, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Crude human uterus extract

  • 阳性对照
    • Crude human uterus extract
  • 常规说明Two isoforms: 205kDa (MHC-1) and 200kDa (MHC-2)

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.05% Sodium Azide
  • 纯度Whole antiserum
  • 克隆单克隆
  • 克隆编号SPM201
  • 同种型IgG
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab17811 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明
    IHC-P: Working dilution: Ready-to-use for 30 min at RT
    Staining of formalin-fixed tissues REQUIRES digesting sections with trypsin at 1mg/ml PBS, 10 min at 37oC, followed by boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min
    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Muscle contraction.
    • 组织特异性Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea.
    • 疾病相关Note=A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.
      Defects in MYH11 are the cause of aortic aneurysm familial thoracic type 4 (AAT4) [MIM:132900]; also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content.
    • 序列相似性Contains 1 IQ domain.
      Contains 1 myosin head-like domain.
    • 结构域The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
      Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
    • 细胞定位Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AAT4 antibody
      • DKFZp686D10126 antibody
      • DKFZp686D19237 antibody
      • FAA4 antibody
      • FLJ35232 antibody
      • KIAA0866 antibody
      • MGC126726 antibody
      • MGC32963 antibody
      • MYH11 antibody
      • MYH11_HUMAN antibody
      • Myosin heavy chain 11 antibody
      • Myosin heavy chain 11 smooth muscle antibody
      • Myosin heavy chain antibody
      • Myosin heavy chain smooth muscle isoform antibody
      • Myosin heavy polypeptide 11 smooth muscle antibody
      • Myosin-11 antibody
      • SM1 antibody
      • SM2 antibody
      • SMHC antibody
      • SMMHC antibody
      • smooth muscle isoform antibody
      • Smooth muscle myosin heavy chain 11 antibody
      see all

    Anti-Myosin, smooth muscle heavy chain 1 and 2 antibody [SPM201], prediluted 图像

    • Human uterus stained with anti-Myosin, (ab17811) 

    Anti-Myosin, smooth muscle heavy chain 1 and 2 antibody [SPM201], prediluted (ab17811)参考文献

    ab17811 has not yet been referenced specifically in any publications.

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