Anti-Myosin, smooth muscle heavy chain 1 and 2抗体[SMMS-1] (ab106919)


  • 产品名称Anti-Myosin, smooth muscle heavy chain 1 and 2抗体[SMMS-1]
    参阅全部 Myosin, smooth muscle heavy chain 1 and 2 一抗
  • 描述
    小鼠单克隆抗体[SMMS-1] to Myosin, smooth muscle heavy chain 1 and 2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Crude Human uterus extract

  • 阳性对照
    • Uterus or normal breast tissue. Some breast cancers, leiomyosarcoma.



Our Abpromise guarantee covers the use of ab106919 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/200. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.


  • 功能Muscle contraction.
  • 组织特异性Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea.
  • 疾病相关Note=A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.
    Defects in MYH11 are the cause of aortic aneurysm familial thoracic type 4 (AAT4) [MIM:132900]; also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content.
  • 序列相似性Contains 1 IQ domain.
    Contains 1 myosin head-like domain.
  • 结构域The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
    Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
  • 细胞定位Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AAT4 antibody
    • DKFZp686D10126 antibody
    • DKFZp686D19237 antibody
    • FAA4 antibody
    • FLJ35232 antibody
    • KIAA0866 antibody
    • MGC126726 antibody
    • MGC32963 antibody
    • MYH11 antibody
    • MYH11_HUMAN antibody
    • Myosin heavy chain 11 antibody
    • Myosin heavy chain 11 smooth muscle antibody
    • Myosin heavy chain antibody
    • Myosin heavy chain smooth muscle isoform antibody
    • Myosin heavy polypeptide 11 smooth muscle antibody
    • Myosin-11 antibody
    • SM1 antibody
    • SM2 antibody
    • SMHC antibody
    • SMMHC antibody
    • smooth muscle isoform antibody
    • Smooth muscle myosin heavy chain 11 antibody
    see all

Anti-Myosin, smooth muscle heavy chain 1 and 2 antibody [SMMS-1] (ab106919)参考文献

This product has been referenced in:
  • Nicolas MM  et al. Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases. Hum Pathol 41:663-71 (2010). Read more (PubMed: 20004935) »

See 1 Publication for this product

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (human smooth muscle cells)
Specification human smooth muscle cells
Fixative Formaldehyde; Methanol; paraformaldehyde
Permeabilization Yes - Triton
Blocking step BSA/Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C

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提交于 Feb 10 2012

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