Anti-Myosin, smooth muscle heavy chain 1 and 2抗体[83B6] (ab97539)


  • 产品名称Anti-Myosin, smooth muscle heavy chain 1 and 2抗体[83B6]
    参阅全部 Myosin, smooth muscle heavy chain 1 and 2 一抗
  • 描述
    小鼠单克隆抗体[83B6] to Myosin, smooth muscle heavy chain 1 and 2
  • 特异性This antibody reacts with all skeletal and cardiac muscle type myosin heavy chains.
  • 经测试应用适用于: WB, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Rat, Rabbit, Chicken, Human
  • 免疫原

    Full length native protein (purified) (Human)

  • 阳性对照
    • Both mammalian and avian strated muscles.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度IgG fraction
  • 克隆单克隆
  • 克隆编号83B6
  • 同种型IgG1
  • 研究领域


Our Abpromise guarantee covers the use of ab97539 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 227 kDa.
IHC-Fr Use at an assay dependent concentration.


  • 功能Muscle contraction.
  • 组织特异性Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea.
  • 疾病相关Note=A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.
    Defects in MYH11 are the cause of aortic aneurysm familial thoracic type 4 (AAT4) [MIM:132900]; also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content.
  • 序列相似性Contains 1 IQ domain.
    Contains 1 myosin head-like domain.
  • 结构域The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
    Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
  • 细胞定位Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AAT4 antibody
    • DKFZp686D10126 antibody
    • DKFZp686D19237 antibody
    • FAA4 antibody
    • FLJ35232 antibody
    • KIAA0866 antibody
    • MGC126726 antibody
    • MGC32963 antibody
    • MYH11 antibody
    • MYH11_HUMAN antibody
    • Myosin heavy chain 11 antibody
    • Myosin heavy chain 11 smooth muscle antibody
    • Myosin heavy chain antibody
    • Myosin heavy chain smooth muscle isoform antibody
    • Myosin heavy polypeptide 11 smooth muscle antibody
    • Myosin-11 antibody
    • SM1 antibody
    • SM2 antibody
    • SMHC antibody
    • SMMHC antibody
    • smooth muscle isoform antibody
    • Smooth muscle myosin heavy chain 11 antibody
    see all

Anti-Myosin, smooth muscle heavy chain 1 and 2 antibody [83B6] (ab97539)参考文献

This product has been referenced in:
  • Wei AY  et al. Characterization of corpus cavernosum smooth muscle cell phenotype in diabetic rats with erectile dysfunction. Int J Impot Res 24:196-201 (2012). WB ; Rat . Read more (PubMed: 22592762) »
  • Dhoot GK  et al. Distribution of isoforms of the myofibrillar proteins in myoid cells of thymus. J Muscle Res Cell Motil 7:351-60 (1986). Read more (PubMed: 2876006) »

See all 2 Publications for this product

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