Anti-Myosin Phosphatase抗体(ab76744)

概述

  • 产品名称Anti-Myosin Phosphatase抗体
    参阅全部 Myosin Phosphatase 一抗
  • 描述
    兔多克隆抗体to Myosin Phosphatase
  • 经测试应用适用于: IHC-Fr, IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from the N terminal domain of human Myosin Phosphatase

性能

应用

Our Abpromise guarantee covers the use of ab76744 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/50 - 1/200.
IHC-P 1/50 - 1/200.
WB 1/100 - 1/1000. Predicted molecular weight: 115 kDa.

靶标

  • 功能Regulates myosin phosphatase activity.
  • 组织特异性Expressed in striated muscles, specifically in type 2a fibers (at protein level).
  • 序列相似性Contains 6 ANK repeats.
  • 发展阶段Induced by 2-fold during pregnancy, including in abdominus rectus muscle.
  • 结构域Heterotetramerization is mediated by the interaction between a coiled-coil of PRKG1 and the leucine/isoleucine zipper of PPP1R12A/MBS, the myosin-binding subunit of the myosin phosphatase.
  • 翻译后修饰Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR.
    In vitro, phosphorylation of Ser-695 by PKA and PKG appears to prevent phosphorylation of the inhibitory site Thr-696, probably mediated by PRKG1.
  • 细胞定位Cytoplasm. Along actomyosin filaments and stress fibers.
  • Information by UniProt
  • 数据库链接
  • 别名
    • M130 antibody
    • MBS antibody
    • Myosin binding subunit antibody
    • Myosin phosphatase target subunit 1 antibody
    • Myosin phosphatase targeting subunit 1 antibody
    • Myosin phosphatase-targeting subunit 1 antibody
    • MYPT1 antibody
    • MYPT1_HUMAN antibody
    • PPP1R12A antibody
    • Protein phosphatase 1 regulatory inhibitor subunit 12A antibody
    • Protein phosphatase 1 regulatory subunit 12A antibody
    • Protein phosphatase 1, regulatory (inhibitor) subunit 12A antibody
    • Protein phosphatase myosin binding subunit antibody
    • Protein phosphatase myosin-binding subunit antibody
    see all

Anti-Myosin Phosphatase antibody (ab76744)参考文献

ab76744 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab76744.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"