Anti-Myosin Phosphatase抗体(ab111237)

概述

  • 产品名称Anti-Myosin Phosphatase抗体
    参阅全部 Myosin Phosphatase 一抗
  • 描述
    山羊多克隆抗体to Myosin Phosphatase
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, correspondin to residues in Human Myosin Phosphatase.

  • 阳性对照
    • Human skeletal muscle tissue

性能

应用

Our Abpromise guarantee covers the use of ab111237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Regulates myosin phosphatase activity.
  • 组织特异性Expressed in striated muscles, specifically in type 2a fibers (at protein level).
  • 序列相似性Contains 6 ANK repeats.
  • 发展阶段Induced by 2-fold during pregnancy, including in abdominus rectus muscle.
  • 结构域Heterotetramerization is mediated by the interaction between a coiled-coil of PRKG1 and the leucine/isoleucine zipper of PPP1R12A/MBS, the myosin-binding subunit of the myosin phosphatase.
  • 翻译后修饰Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR.
    In vitro, phosphorylation of Ser-695 by PKA and PKG appears to prevent phosphorylation of the inhibitory site Thr-696, probably mediated by PRKG1.
  • 细胞定位Cytoplasm. Along actomyosin filaments and stress fibers.
  • Information by UniProt
  • 数据库链接
  • 别名
    • M130 antibody
    • MBS antibody
    • Myosin binding subunit antibody
    • Myosin phosphatase target subunit 1 antibody
    • Myosin phosphatase targeting subunit 1 antibody
    • Myosin phosphatase-targeting subunit 1 antibody
    • MYPT1 antibody
    • MYPT1_HUMAN antibody
    • PPP1R12A antibody
    • Protein phosphatase 1 regulatory inhibitor subunit 12A antibody
    • Protein phosphatase 1 regulatory subunit 12A antibody
    • Protein phosphatase 1, regulatory (inhibitor) subunit 12A antibody
    • Protein phosphatase myosin binding subunit antibody
    • Protein phosphatase myosin-binding subunit antibody
    see all

Anti-Myosin Phosphatase antibody 图像

  • ab111237, at 3.75 µg/ml, staining Myosin Phosphatase in formalin fixed, paraffin embedded Human skeletal muscle tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase streptavidin and chromogen.

Anti-Myosin Phosphatase antibody (ab111237)参考文献

ab111237 has not yet been referenced specifically in any publications.

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